TRANSCRIPTOME PROFILING IDENTIFIES GENES AND PATHWAYS DEREGULATED UPON FLOXURIDINE TREATMENT IN COLORECTAL CANCER CELLS HARBORING GOF MUTANT P53

Transcriptome profiling identifies genes and pathways deregulated upon floxuridine treatment in colorectal cancer cells harboring GOF mutant p53

Mutation in TP53 is a common genetic alteration in human cancers.Certain tumor associated p53 missense mutants acquire gain-of-function (GOF) properties and confer oncogenic phenotypes Brides including enhanced chemoresistance.The colorectal cancers (CRC) harboring mutant p53 are generally aggressive in nature and difficult to treat.To identify a p

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Keratin 8 expression in head and neck epithelia

Abstract Background The intermediate filament forming protein keratin 8 (K8) is a tumour-associated antigen, which was shown to be over-expressed in a variety of malignancies.Here, we present a study of K8 expression in squamous epithelia of the head and neck area, including normal mucosa, hyperplastic and dysplastic leukoplakia, carcinomas of diff

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